A theoretical study on the molecular determinants of the affibody protein ZAβ3bound to an amyloid β peptide-Reference-Cited by-同舟云学术

A theoretical study on the molecular determinants of the affibody protein ZAβ3bound to an amyloid β peptide

Published:2015 Issue:26 Volume:17 Page:16886-16893
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Wang Xu¹²³⁴⁵,Sun Xianqiang¹²³⁴⁵,Kuang Guanglin¹²³⁴⁵,Ågren Hans¹²³⁴⁵,Tu Yaoquan¹²³⁴⁵

Affiliation:

1. Division of Theoretical Chemistry and Biology

2. School of Biotechnology

3. KTH Royal Institute of Technology

4. S-106 91 Stockholm

5. Sweden

Abstract

The investigation of the (Z_Aβ3)₂:Aβ complex highlights the energetic contribution of affibody residues to the binding with alzheimer's disease associated Aβ peptides.

Funder

Stiftelsen för?Strategisk Forskning

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CP/C5CP00615E

Reference47 articles.

1. Alzheimer's Disease

2. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

3. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

4. Translating cell biology into therapeutic advances in Alzheimer's disease

5. Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability

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