Photocatalytic intermolecular bromonitroalkylation of styrenes: synthesis of cyclopropylamine derivatives and their evaluation as LSD1 inhibitors-Reference-Cited by-同舟云学术

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Photocatalytic intermolecular bromonitroalkylation of styrenes: synthesis of cyclopropylamine derivatives and their evaluation as LSD1 inhibitors

Published:2024 Issue:2 Volume:14 Page:831-835
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kim Darong¹,Jeon Hui-Jeon¹,Kwak Yoonna¹,Lee Sun Joo¹,Nam Tae-Gyu²^ORCID,Yu Ji Hoon¹,An Hongchan³,Hong Ki Bum¹^ORCID

Affiliation:

1. New Drug Development Center (NDDC), Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), 80 Cheombok-ro, Dong-gu, Daegu 41061, Republic of Korea

2. Department of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan, Gyeonggi-do 15588, Republic of Korea

3. College of Pharmacy, Institute of Pharmaceutical Sciences, CHA University, 120 Haeryong-ro, Pocheon-si, Gyeonggi-do 11160, Republic of Korea

Abstract

A mild and efficient method for photoredox-catalyzed bromonitroalkylation of alkenes is described herein.

Funder

Ministry of Trade, Industry and Energy

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA07830B

Reference20 articles.

1. Regulation of chromatin structure by site-specific histone H3 methyltransferases

2. Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

3. p53 is regulated by the lysine demethylase LSD1

4. Lysine Methylation Regulates E2F1-Induced Cell Death

5. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

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