A dual approach to cancer treatment: gold(<scp>i</scp>) terpyridine derivatives as DNA binders and inhibitors of mammalian thioredoxin reductase-Reference-Cited by-同舟云学术

A dual approach to cancer treatment: gold(i) terpyridine derivatives as DNA binders and inhibitors of mammalian thioredoxin reductase

Published:2024 Issue:15 Volume:11 Page:4802-4814
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Gil-Moles María¹²³,Olmos M. Elena²^ORCID,López-de-Luzuriaga José M.²^ORCID,Ott Ingo³,Concepción Gimeno M.¹^ORCID

Affiliation:

1. Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, 50009 Zaragoza, Spain

2. Departamento de Química, Universidad de La Rioja. Instituto de Investigación en Química (IQUR). Complejo Científico-Tecnológico, Madre de Dios 53, 26006-Logroño, Spain

3. Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstr. 55, 38106 Braunschweig, Germany

Abstract

Gold(i) terpyridine derivatives exhibiting exceptional cytotoxic activity against critical cancer types are elucidated. Significantly, these compounds demonstrate dual functionality by interacting with DNA and inhibiting TrxR.

Funder

Departamento de Educación, Cultura y Deporte, Gobierno de Aragón

Agencia Estatal de Investigación

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QI/D4QI00755G

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