Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease
Author:
Affiliation:
1. Department of Chemistry
2. University of California
3. Berkeley
4. USA
5. Nuclear and Chemical Sciences Division
6. Lawrence Livermore National Laboratory
7. Livermore
8. Howard Hughes Medical Institute
Abstract
Coregistering quantitative high-resolution metal imaging with fluorescence imaging identifies copper accumulation in megamitochondria within intact neuroretinal slices.
Funder
Hertz Foundation
U.S. Department of Energy
National Institutes of Health
Canadian Institute for Advanced Research
Howard Hughes Medical Institute
Publisher
Oxford University Press (OUP)
Subject
Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2018/MT/C7MT00349H
Reference73 articles.
1. Copper trafficking to the secretory pathway
2. How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1
3. Menkes disease: what a multidisciplinary approach can do
4. Modifying factors and phenotypic diversity in Wilson's disease
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