A unifying view of the broad-spectrum antiviral activity of RSAD2 (viperin) based on its radical-SAM chemistry-Reference-Cited by-同舟云学术

A unifying view of the broad-spectrum antiviral activity of RSAD2 (viperin) based on its radical-SAM chemistry

Published:2018 Issue:4 Volume:10 Page:539-552
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Honarmand Ebrahimi Kourosh¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Oxford

3. Oxford

4. UK

Abstract

A unifying model for the broad-spectrum antiviral activity of a metalloenzyme of the inborn immune system named RSAD2 (viperin) is proposed based on the radical-SAM catalytic activity of the enzyme.

Funder

European Molecular Biology Organization

European Cooperation in Science and Technology

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MT/C7MT00341B

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3. S-Adenosylmethionine-dependent radical-based modification of biological macromolecules

4. S-adenosylmethionine as an oxidant: the radical SAM superfamily

5. Structure and function of radical SAM enzymes

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