A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans

Author:

García-García Amalia1ORCID,Rojas Sara1ORCID,Rivas-García Lorenzo2ORCID,Navarro-Hortal María D.3ORCID,Romero-Márquez Jose M.3ORCID,Fernández-Bolaños José G.4ORCID,Choquesillo-Lazarte Duane5ORCID,Salinas-Castillo Alfonso6ORCID,López Óscar4ORCID,Quiles José L.37ORCID,Rodríguez-Diéguez Antonio1ORCID

Affiliation:

1. Department of Inorganic Chemistry, Faculty of Sciences, University of Granada, Av. Fuentenueva S/N, Granada 18071, Spain

2. Department of Physiology, University of Granada, Granada 18071, Spain

3. Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Centre, Department of Physiology, University of Granada, Avda. del Conocimiento s.n, Armilla 18100, Spain

4. Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Apart. 1203, Seville E-41071, Spain

5. Laboratorio de Estudios Cristalográficos, IACT, CSIC-UGR, Av. Las Palmeras n°4, Granada 18100, Spain

6. Department of Analytic Chemistry, Faculty of Sciences, University of Granada, Av. Fuentenueva S/N, Granada 18071, Spain

7. Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres, 21, Santander 39011, Spain

Abstract

A new palladium coordination compound shows promising protective activity against Aβ-induced toxicity.

Funder

Ministerio de Ciencia e Innovación

Junta de Andalucía

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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