Effect of osmolytes on the thermal stability of proteins: replica exchange simulations of Trp-cage in urea and betaine solutions-Reference-Cited by-同舟云学术

Effect of osmolytes on the thermal stability of proteins: replica exchange simulations of Trp-cage in urea and betaine solutions

Published:2018 Issue:16 Volume:20 Page:11174-11182
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Adamczak Beata¹²³⁴,Kogut Mateusz¹²³⁴^ORCID,Czub Jacek¹²³⁴^ORCID

Affiliation:

1. Department of Physical Chemistry

2. Gdansk University of Technology

3. Gdansk

4. Poland

Abstract

Although osmolytes are known to modulate the folding equilibrium, the molecular mechanism of their effect on thermal denaturation of proteins is still poorly understood.

Funder

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CP/C7CP07436K

Reference66 articles.

1. A molecular mechanism for osmolyte-induced protein stability

2. Influence of Osmolytes on Protein and Water Structure: A Step To Understanding the Mechanism of Protein Stabilization

3. Cosolvent Effects on Protein Stability

4. Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO)

5. The molecular basis for the chemical denaturation of proteins by urea

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Designing Formulation Strategies for Enhanced Stability of Therapeutic Peptides in Aqueous Solutions: A Review;Pharmaceutics;2023-03-14

2. Cosolvent Exclusion Drives Protein Stability in Trimethylamine N-Oxide and Betaine Solutions;The Journal of Physical Chemistry Letters;2022-08-19

3. Mechanism of Osmolyte Stabilization–Destabilization of Proteins: Experimental Evidence;The Journal of Physical Chemistry B;2022-04-20

4. Structural studies of Myceliophthora Thermophila Laccase in the presence of deep eutectic solvents;Enzyme and Microbial Technology;2021-10

5. Insights into the Molecular-Level details of betaine interactions with Laccase under various thermal conditions;Journal of Molecular Liquids;2021-10