Organocatalytic site- and stereoselective 1,6-additions of N-aryl-3-oxobutanamides to propargylic aza-p-quinone methides-Reference-Cited by-同舟云学术

Organocatalytic site- and stereoselective 1,6-additions of N-aryl-3-oxobutanamides to propargylic aza-p-quinone methides

Published:2020 Issue:21 Volume:7 Page:3446-3451
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Li Fushuai¹²³⁴⁵,Chen Xuling⁶⁷⁸⁹¹⁰,Liang Shuai¹²³⁴⁵,Shi Zhenyan¹²³⁴⁵,Li Pengfei⁶⁷⁸⁹¹⁰^ORCID,Li Wenjun¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Qingdao University

4. Qingdao

5. China

6. Shenzhen Grubbs Institute

7. Department of Chemistry

8. Guangdong Provincial Key Laboratory of Catalysis

9. Southern University of Science and Technology

10. Shenzhen

Abstract

A chiral phosphoric acid catalyzed site-selective 1,6-conjugate addition of N-aryl-3-oxobutanamides to in situ formed propargylic aza-p-quinone methides from propargylic alcohols has been established for the first time.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/QO/D0QO00888E

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5. Conjugate Additions of Nitroalkanes to Electron-Poor Alkenes: Recent Results

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