Synthesis and biological profiling of parthenolide ether analogs-Reference-Cited by-同舟云学术

Synthesis and biological profiling of parthenolide ether analogs

Published:2019 Issue:45 Volume:17 Page:9703-9707
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Freund Robert R. A.¹²³⁴^ORCID,Gobrecht Philipp⁵⁶⁷⁴,Moser Pascal¹²³⁴^ORCID,Fischer Dietmar⁵⁶⁷⁴^ORCID,Arndt Hans-Dieter¹²³⁴^ORCID

Affiliation:

1. Institut für Organische Chemie und Makromolekulare Chemie

2. Friedrich-Schiller-Universität

3. 07743 Jena

4. Germany

5. Lehrstuhl für Zellphysiologie

6. Ruhr-Universität Bochum

7. 44780 Bochum

Abstract

Cyclic ether derivatives of parthenolide were synthesized by using two cyclization strategies, relying on 2-(silyloxy) allylboration. Characterization for tubulin carboxypeptidase inhibition generated new insights into structure–activity relationships.

Funder

Thüringer Ministerium für Wirtschaft, Wissenschaft und Digitale Gesellschaft

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB02166C

Reference43 articles.

1. On terpenes. CXVIII. Constitution of parthenolide

2. Tumor Inhibitory Agent from Magnolia grandiflora (Magnoliaceae) I: Parthenolide