Discovery of 3,3a,4,5-tetrahydro-2H-benzo[g]indazole containing quinoxaline derivatives as novel EGFR/HER-2 dual inhibitors-Reference-Cited by-同舟云学术

Discovery of 3,3a,4,5-tetrahydro-2H-benzo[g]indazole containing quinoxaline derivatives as novel EGFR/HER-2 dual inhibitors

Published:2015 Issue:32 Volume:5 Page:24814-24823
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zong Xi¹²³⁴,Cai Jin¹²³⁴,Chen Junqing¹²³⁴,Sun Chunlong¹²³⁴,Li Lushen⁵²³⁴,Ji Min⁵²³⁴⁶

Affiliation:

1. School of Chemistry & Chemical Engineering

2. Southeast University

3. Nanjing 210096

4. China

5. School of Biological Science & Medical Engineering

6. Suzhou Key Laboratory of Biomaterials and Technologies & Collaborative Innovation Center of Suzhou Nano Science and Technology

Abstract

A series of pyrazole–quinoxaline derivatives were synthesized and most of them exhibited potent affinity for EGFR or HER-2 kinase, as well as excellent antiproliferative activity, with compound 4l being the most active.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA02576A

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