Chirality-dependent supramolecular synthons based on the 1,3-oxazolidin-2-one framework: chiral drugs mephenoxalone, metaxalone and 114 other examples-Reference-Cited by-同舟云学术

Chirality-dependent supramolecular synthons based on the 1,3-oxazolidin-2-one framework: chiral drugs mephenoxalone, metaxalone and 114 other examples

Published:2020 Issue:43 Volume:22 Page:7252-7261
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Bredikhin Alexander A.¹²³⁴^ORCID,Bredikhina Zemfira A.¹²³⁴,Gubaidullin Aidar T.¹²³⁴^ORCID

Affiliation:

1. Arbuzov Institute of Organic and Physical Chemistry

2. FRC Kazan Scientific Center of RAS

3. Kazan 420088

4. Russian Federation

Abstract

Analysis of the 119 crystal structures of 1,3-oxazolidin-2-one derivatives, including the chiral muscle relaxants mephenoxalone and metaxalone, showed that cyclic motifs dominate in racemic, and linear in single-enantiomeric, samples.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CE/D0CE00116C

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