Potentiating bisphosphonate-based coordination complexes to treat osteolytic metastases

Author:

Quiñones Vélez Gabriel12345ORCID,Carmona-Sarabia Lesly12345ORCID,Rodríguez-Silva Waldemar A.67245ORCID,Rivera Raíces Alondra A.67245ORCID,Feliciano Cruz Lorraine67245ORCID,Hu Tony89105ORCID,Peterson Esther112345ORCID,López-Mejías Vilmalí12345ORCID

Affiliation:

1. Department of Chemistry

2. University of Puerto Rico

3. Río Piedras

4. San Juan

5. USA

6. Crystallization Design Institute

7. Molecular Sciences Research Center

8. Department of Chemistry and the Molecular Design Institute

9. New York University

10. New York

11. Department of Biology

Abstract

The phase-inversion hydrothermal synthesis of alendronate and Ca(ii) promotes the formation of a coordination complex whose solid-state, stability, particle size and cytotoxicity were assessed and optimized to potentiate its biomedical applications.

Funder

National Science Foundation

Universidad de Puerto Rico

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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