New total synthesis and structure confirmation of putative (+)-hyacinthacine C3 and (+)-5-epi-hyacinthacine C3-Reference-Cited by-同舟云学术

New total synthesis and structure confirmation of putative (+)-hyacinthacine C3 and (+)-5-epi-hyacinthacine C3

Published:2021 Issue:50 Volume:11 Page:31621-31630
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Dikošová Lívia¹,Otočková Barbora¹,Malatinský Tomáš¹,Doháňošová Jana²,Kopáčová Mária³,Ďurinová Anna⁴,Smutná Lucie⁴,Trejtnar František⁴,Fischer Róbert¹^ORCID

Affiliation:

1. Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology in Bratislava, Radlinského 9, 812 37 Bratislava, Slovak Republic

2. Central Laboratories, Slovak University of Technology in Bratislava, Radlinského 9, 812 37 Bratislava, Slovak Republic

3. Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovak Republic

4. Charles University, Faculty of Pharmacy in Hradec Kralove, Heyrovskeho 1203, 50005 Hradec Kralove, Czech Republic

Abstract

A second total synthesis of (+)-hyacinthacine C3 is reported. As a result, structure of the first synthetically prepared alkaloid is proved to be correct, clearly confirming the inconsistency with the stereochemistry assigned to the natural sample.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA06225E

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