Discovery of pentaene polyols by the activation of an enediyne gene cluster: biosynthetic implications for 9-membered enediyne core structures-Reference-Cited by-同舟云学术

Discovery of pentaene polyols by the activation of an enediyne gene cluster: biosynthetic implications for 9-membered enediyne core structures

Published:2022 Issue:45 Volume:13 Page:13475-13481
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Pan Jian¹^ORCID,Tan Qingwen¹,Zhu Saibin¹,Yan Xiaohui²,Li Yu¹,Zhuang Zhoukang¹,Zhu Xiangcheng¹³,Duan Yanwen¹⁴³,Huang Yong¹⁴^ORCID

Affiliation:

1. Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan 410013, China

2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China, State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China

3. National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, Changsha, Hunan 410205, China

4. Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery, Changsha, Hunan 410205, China

Abstract

Production of three new pentaene polyols 5–7 by an activated enediyne gene cluster and their biosynthetic study suggest the presence of a polyene epoxide intermediate during the early steps of 9-membered enediyne core formation.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Hunan Provincial Innovation Foundation for Postgraduate

Fundamental Research Funds for the Central Universities

Science and Technology Program of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC04379C