The influence of surface charge on the tumor-targeting behavior of Fe3O4 nanoparticles for MRI-Reference-Cited by-同舟云学术

The influence of surface charge on the tumor-targeting behavior of Fe3O4 nanoparticles for MRI

Published:2022 Issue:4 Volume:10 Page:646-655
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Yue Saisai¹,Zhang Xin²,Xu Yuping¹,Zhu Lichong¹,Cheng Junwei¹,Qiao Yuanyuan¹,Dai Suyang¹,Zhu Jialin³,Jiang Ni¹,Wu Hao⁴,Zhang Peisen¹,Hou Yi¹⁵^ORCID

Affiliation:

1. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

2. Department of Engineering and Transformation Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China

3. Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China

4. The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China

5. Department of Nanomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai 200433, China

Abstract

The effect of surface charge on the tumor-targeting in vivo is different from that at cell level. The neutral nanoparticles exhibit stronger tumor uptake, while the charged ones accelerate the RES/MPS uptake, making their active-targeting useless.

Funder

National Natural Science Foundation of China

Beijing Municipal Natural Science Foundation

Fundamental Research Funds for the Central Universities

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D1TB02349G

Reference46 articles.