NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline-Reference-Cited by-同舟云学术

NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline

Published:2022 Issue:2 Volume:7 Page:269-274
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Di Carmine Graziano¹²^ORCID,Forster Luke²^ORCID,Wang Simeng²,Parlett Christopher²³⁴⁵^ORCID,Carlone Armando⁶^ORCID,D'Agostino Carmine²^ORCID

Affiliation:

1. Department of Chemical, Pharmaceutical and Agricultural Sciences (DOCPAS), University of Ferrara, Via Luigi Borsari 46, I-44121, Ferrara, Italy

2. Department of Chemical Engineering and Analytical Science (CEAS), The University of Manchester, M13 9PL, Manchester, UK

3. Diamond Light Source, Harwell Science and Innovation Campus, OX11 0DE, Didcot, Oxfordshire, UK

4. The University of Manchester at Harwell, Harwell Science and Innovation Campus, OX11 0DE, Didcot, Oxfordshire, UK

5. Catalysis Hub, Research Complex at Harwell, Rutherford Appleton Laboratory, OX11 0FA, Harwell, Oxfordshire, UK

6. Department of Physical and Chemical Sciences, Università degli Studi dell'Aquila, Via Vetoio, 67100 L'Aquila, Italy

Abstract

The behaviour of solvents in solid-supported proline organocatalysts is explored using NMR relaxation measurements coupled with reaction screening. Solvents with a lower affinity for the solid surface lead to a higher reactivity.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RE/D1RE00471A

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