The influence of chirality on the behavior of oligonucleotides inside cells: revealing the potent cytotoxicity of G-rich <scp>l</scp>-RNA-Reference-Cited by-同舟云学术

The influence of chirality on the behavior of oligonucleotides inside cells: revealing the potent cytotoxicity of G-rich l-RNA

Published:2023 Issue:5 Volume:14 Page:1145-1154
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yu Chen-Hsu¹,Sczepanski Jonathan T.¹^ORCID

Affiliation:

1. Department of Chemistry, Texas A&M University, College Station, Texas, 77843, USA

Abstract

We determined the influence of chirality on the behavior of oligonucleotides inside human cells, revealing that mirror-image l-oligonucleotides have the potential to be highly cytotoxic.

Funder

National Institute of General Medical Sciences

Welch Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC05511B

Reference48 articles.

1. Mirror‐Image Oligonucleotides: History and Emerging Applications

2. Utilising the left-helical conformation of L-DNA for analysing different marker types on a single universal microarray platform

3. Synthesis and properties of mirror-image DNA

4. Stereospecificity of Oligonucleotide Interactions Revisited: No Evidence for Heterochiral Hybridization and Ribozyme/DNAzyme Activity

5. Mirror-image DNA

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1. Heterochiral modifications enhance robustness and function of DNA in living human cells;ChemBioChem;2024-02-12

2. Synthesis of 2′-O-Methyl/2′-O-MOE-L-Nucleoside Derivatives and Their Applications: Preparation of G-Quadruplexes, Their Characterization, and Stability Studies;ACS Omega;2023-11-13

3. Chimeric d/l-DNA Probes of Base Excision Repair Enable Real-Time Monitoring of Thymine DNA Glycosylase Activity in Live Cells;Journal of the American Chemical Society;2023-07-26

4. Correction: The influence of chirality on the behavior of oligonucleotides inside cells: revealing the potent cytotoxicity of G-rich l-RNA;Chemical Science;2023