Molecular insight into the differential anti-androgenic activity of resveratrol and its natural analogs: in silico approach to understand biological actions

Author:

Chakraborty Sandipan12345,Kumar Avinash6785,Butt Nasir A.67859,Zhang Liangfen9785,Williams Raquema12345,Rimando Agnes M.101112135,Biswas Pradip K.12345,Levenson Anait S.67859

Affiliation:

1. Laboratory of Computational Biophysics & Bioengineering

2. Department of Physics

3. Tougaloo College

4. Tougaloo

5. USA

6. Cancer Institute

7. University of Mississippi Medical Center

8. Jackson

9. Department of Pathology

10. United States Department of Agriculture

11. Agriculture Research Service

12. Natural Products Utilization Research Unit

13. University

Abstract

Our integrated experimental andin silicoapproach revealed pterostilbene as the most potent anti-androgenic compound among natural stilbenes.

Funder

Office of Experimental Program to Stimulate Competitive Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Reference48 articles.

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3. Diverse roles of androgen receptor (AR) domains in AR-mediated signaling

4. Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer

5. Molecular basis for gene-specific transactivation by nuclear receptors

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