Synthesis of pyrazolo[5′,1′:2,3]imidazo[1,5-<i>c</i>]quinazolin-6(5<i>H</i>)-ones and molecular docking study of their affinity against the COVID-19 main protease-Reference-Cited by-同舟云学术

Synthesis of pyrazolo[5′,1′:2,3]imidazo[1,5-c]quinazolin-6(5H)-ones and molecular docking study of their affinity against the COVID-19 main protease

Published:2022 Issue:30 Volume:12 Page:19579-19589
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Saeedi Shaghayegh¹,Rahmati Abbas¹^ORCID,Chavoshpour-Natanzi Zahra¹

Affiliation:

1. Department of Chemistry, University of Isfahan, P. O. Box 81746-73441, Isfahan, Iran

Abstract

A novel series of fused pyrazolo[5′,1′:2,3]imidazo[1,5-c]quinazolin-6(5H)-ones were synthesized and their affinity against the COVID-19 main protease was investigated using molecular docking study and compared to that of some used clinical drugs.

Funder

University of Isfahan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA03179E

Reference41 articles.

1. Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

2. Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

3. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals