New bedaquiline salt with improved bioavailability and reduced food effect-Reference-Cited by-同舟云学术

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New bedaquiline salt with improved bioavailability and reduced food effect

Published:2024 Issue: Volume: Page:
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Zhang Xiaowen¹²,Meng Dongshuo¹²,Zang Zongwu²,Xu Zhiru²,Liu Yu¹²^ORCID

Affiliation:

1. Incubation Center for Science and Technology Achievements, China State Institute of Pharmaceutical Industry Co Ltd, Shanghai 201203, P. R. China

2. National Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry Co Ltd., China State Institute of Pharmaceutical Industry Co Ltd., Shanghai 201203, P. R. China

Abstract

A novel salt form of bedaquiline has been designed and prepared, which demonstrates superior in vivo absorption and reduced the food effect compared to commercially available products.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CE/D4CE00567H

Reference21 articles.

1. A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis

2. Bedaquiline: First FDA-approved tuberculosis drug in 40 years

3. A review of tuberculosis: Focus on bedaquiline

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