Enhanced flow synthesis of small molecules by in-line integration of sequential catalysis and benchtop twin-column continuous chromatography-Reference-Cited by-同舟云学术

Enhanced flow synthesis of small molecules by in-line integration of sequential catalysis and benchtop twin-column continuous chromatography

Published:2022 Issue:12 Volume:7 Page:2650-2658
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Sivo Alessandra¹,Kim Tae Keun¹^ORCID,Ruta Vincenzo¹,Luisi Renzo²^ORCID,Osorio-Tejada Jose³^ORCID,Escriba-Gelonch Marc⁴^ORCID,Hessel Volker⁵^ORCID,Sponchioni Mattia¹^ORCID,Vilé Gianvito¹^ORCID

Affiliation:

1. Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, IT-20131 Milano, Italy

2. Department of Pharmacy – Drug Sciences, University of Bari “A. Moro”, Via E. Orabona 4, IT-70125 Bari, Italy

3. School of Engineering, The University of Warwick, CV4 7AL, Coventry, UK

4. University of Lleida, Higher Polytechnic Engineering School, Igualada, Spain

5. School of Chemical Engineering and Advanced Materials, The University of Adelaide, North Terrace Campus, Adelaide, 5005, Australia

Abstract

In-line integration of sequential catalysis and continuous multi-column purification. Adapted for small compound amounts (hit-to-lead). Suitable for large-scale purification (process chemistry).

Funder

European Commission

Fondazione Bracco

Bracco Imaging

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RE/D2RE00242F

Reference42 articles.

1. A Multifunctional Microfluidic Platform for High‐Throughput Experimentation of Electroorganic Chemistry