Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors
Author:
Affiliation:
1. Department of Chemistry
2. University of Liverpool
3. Liverpool L69 7ZD
4. UK
5. Department of Biochemistry
6. Institute of Integrative Biology
7. Liverpool L69 7ZB
Abstract
Regulated sulfation of biomolecules by sulfotransferases (STs) plays a role in many biological processes with implications for a number of disease areas. A structure-based approach and molecular docking were used to design a library of ST inhibitors.
Funder
H2020 Future and Emerging Technologies
Biotechnology and Biological Sciences Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA07567D
Reference77 articles.
1. Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer
2. Human Sulfotransferases and Their Role in Chemical Metabolism
3. Sulfotransferases: Structure, Mechanism, Biological Activity, Inhibition, and Synthetic Utility
4. Structure and Function of Sulfotransferases
5. Tyrosine Sulfation as a Protein Post-Translational Modification
Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. A comprehensive review on structural and therapeutical insight of Cerebroside sulfotransferase (CST) - An important target for development of substrate reduction therapy against metachromatic leukodystrophy;International Journal of Biological Macromolecules;2024-02
2. Design, synthesis and biological evaluation of Nucleosidic CD99 inhibitors that selectively reduce Ewing sarcoma viability;European Journal of Medicinal Chemistry;2023-05
3. From Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor Function;Drug Metabolism and Disposition;2022-02-22
4. Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity;Organic & Biomolecular Chemistry;2022
5. Binding Mode Prediction and Identification of New Lead Compounds from Natural Products as 3-OST Enzyme Inhibitors;Letters in Drug Design & Discovery;2020-09-11
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3