Three new coordination geometries of homoleptic Zn complexes of curcuminoids and their high antiproliferative potential

Author:

Meza-Morales William12,Alvarez-Ricardo Yair1,Obregón-Mendoza Marco A.1,Arenaza-Corona Antonino1,Ramírez-Apan María Teresa1,Toscano Rubén A.1,Poveda-Jaramillo Juan Carlos3ORCID,Enríquez Raúl G.1ORCID

Affiliation:

1. Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City, C.P. 04510, Mexico

2. Department of Chemical Engineering, University of Puerto Rico-Mayaguez, Route 108, Mayaguez, Puerto Rico, USA

3. Laboratorio de Resonancia Magnética Nuclear, Universidad Industrial de Santander, Sede Guatiguará Km. 2 vía El Refugio, 681011 Piedecuesta, Santander, Colombia

Abstract

We add herein three new geometries of homoleptic type complexes i.e. octahedral, trigonal-pyramidal, and trigonal-bipyramidal. Moreover, the IC50 values for the DiMeOC-Zn complex were 8 or 22 times higher than cisplatin in the U251 and HCT15 cell lines.

Funder

Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México

Consejo Nacional de Ciencia y Tecnología

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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