Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment-Reference-Cited by-同舟云学术

Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment

Published:2018 Issue:7 Volume:8 Page:3564-3573
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chay Sai Kin¹²³^ORCID,Keating Alison V.¹²³,James Colin¹²³,Aliev Abil E.⁴⁵³,Haider Shozeb¹²³^ORCID,Craig Duncan Q. M.¹²³^ORCID

Affiliation:

1. University College London School of Pharmacy

2. London WC1N 1AX

3. UK

4. University College London Department of Chemistry

5. London WC1H 0AJ

Abstract

A correlation between taste masking, assessed using a taste sensor system, and inclusion complex formation, assessed using NMR and molecular docking studies, has been identified for ranitidine HCl and (2-hydroxypropyl)-β-cyclodextrin.

Funder

Pfizer UK

EPSRC

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C7RA11015D

Reference30 articles.

1. Rational development of taste masked oral liquids guided by an electronic tongue

2. The molecular physiology of taste transduction