Sulfated galactofucan from Sargassum thunbergii induces senescence in human lung cancer A549 cells

Author:

Bao Yizhong12345ORCID,He Xinyue6785,Wu Wanli6785,Wang Sanying12345,Dai Jihuan12345,Zhang Zhongshan910111213,Jin Weihua6785,Yan Jing12345,Mao Genxiang12345ORCID

Affiliation:

1. Zhejiang Provincial Key Lab of Geriatrics

2. Department of Geriatrics

3. Zhejiang Hospital

4. Hangzhou 310013

5. PR China

6. College of Biotechnology and Bioengineering

7. Zhejiang University of Technology

8. Hangzhou 310014

9. Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province

10. Huzhou University

11. Huzhou 313000

12. China

13. Huzhou Cent Hosp

Abstract

Our data indicated that a sulfated galactofucan (SWZ-4-H) from Sargassum thunbergii could induce lung cancer cell senescence by regulating p53, p21, p16, and p-Rb.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Natural Science Foundation of Zhejiang Province

Science and Technology Department of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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