Conjugated linoleic acid (CLA) reduces intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway

Author:

Zhang Fenglin1,Fu Yiming1,Wang Junfeng1,Lang Limin1,Liang Shuyi1,Zhang Shilei1,Wang Lina1ORCID,Gao Ping1,Shu Gang1,Zhu Canjun1,Wu Ruifan1,Jiang Qingyan1ORCID,Wang Songbo12ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Animal Nutrition Control and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P. R. China

2. Yunfu Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Wens Foodstuff Group Co., Ltd.,Yunfu 527400, P. R. China

Abstract

CLA reduced intestinal fatty acids uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and downstream ERK pathway.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

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