A vertical-flow bioreactor array compacts hepatocytes for enhanced polarity and functions-Reference-Cited by-同舟云学术

A vertical-flow bioreactor array compacts hepatocytes for enhanced polarity and functions

Published:2016 Issue:20 Volume:16 Page:3898-3908
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Zhu Liang¹²³⁴⁵,Xia Huanming⁵⁶⁷⁸⁹,Wang Zhenfeng⁵⁶,Fong Eliza Li Shan¹⁰¹¹¹²⁴,Fan Junjun¹³¹⁴¹⁵⁴¹⁶,Tong Wen Hao¹⁰¹¹¹²⁴¹³,Seah Yen Peng Daphne⁵⁶,Zhang Weian¹⁰¹¹¹²⁴,Li Qiushi¹²³⁴,Yu Hanry¹²³⁴¹⁰^ORCID

Affiliation:

1. Mechanobiology Institute

2. National University of Singapore

3. Singapore 117411

4. Singapore

5. Singapore Institute of Manufacturing Technology

6. 638075 Singapore

7. School of Mechanical Engineering

8. Nanjing University of Science and Technology

9. Nanjing

10. Department of Physiology

11. Yong Loo Lin School of Medicine

12. Singapore 117597

13. Institute of Biotechnology and Nanotechnology

14. A*STAR

15. Singapore 138669

16. Singapore-MIT Alliance for Research and Technology

Abstract

Compaction by vertical flow perfusion induces anin vivo-like cuboidal morphology of hepatocytes in monolayer culture, which enhances polarity and hepatic functions in long-termin vitroculture for drug testing applications.

Funder

Agency for Science, Technology and Research

National Medical Research Council

Singapore-MIT Alliance for Research and Technology Centre

Janssen Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2016/LC/C6LC00811A

Reference36 articles.