Enzymatic modification of d-mannose alleviates DSS-induced colonic inflammation in mice through macrophage polarization mediated by PPARγ

Author:

Liu Yanjun12,Li Ziwei3,Xu Yongjiang1,Liu Yuanfa1,Xue Changhu24ORCID

Affiliation:

1. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, 1800 Lihu Road, Wuxi 214122, Jiangsu, China

2. College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China

3. Wuxi Food Safety Inspection and Test Center, Technology Innovation Center of Special Food for State Market Regulation, 214142, Wuxi, China

4. Qingdao National Laboratory for Marine Science and Technology, 266235, Qingdao, Shandong Province, China

Abstract

As a dietary supplement, enzymatic modification of mannose (phosphatidylmannoside, PtdMan) via phospholipase d catalyzed transphosphatidylation is to be used as a way to enhance the modulatory effect of mannose on colitis.

Funder

Ocean University of China

Jiangnan University

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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