Maillard-type glycated collagen with alginate oligosaccharide suppresses inflammation and oxidative stress by attenuating the expression of LPS receptors Tlr4 and Cd14 in macrophages

Author:

Yang Boxue12ORCID,Li Wenzhao1,Saeki Hiroki1ORCID,Shimizu Yutaka1,Joe Ga-Hyun1ORCID

Affiliation:

1. Faculty of Fisheries Sciences, Hokkaido University, Minato 3, Hakodate, Hokkaido 041-8611, Japan

2. Liaoning Ocean and Fisheries Science Research Institute, Dalian, Liaoning, 116023, PR China

Abstract

18h AO-glycated collagen (C-AO) reduced LPS receptor expression, enhancing anti-inflammatory and anti-oxidant effects in macrophages. C-AO shows potential in disease prevention and inflammation management.

Funder

Hokkaido University

Publisher

Royal Society of Chemistry (RSC)

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