Diastereodivergent construction of bispiro[oxindole-bi-pyrrolidine]s with four consecutive stereocentersviaasymmetric [3 + 2] cycloaddition of 2,3-dioxopyrrolidines using identical catalysts-Reference-Cited by-同舟云学术

Diastereodivergent construction of bispiro[oxindole-bi-pyrrolidine]s with four consecutive stereocentersviaasymmetric [3 + 2] cycloaddition of 2,3-dioxopyrrolidines using identical catalysts

Published:2019 Issue:12 Volume:6 Page:1989-1995
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhao Xiaoyun¹²³⁴,Xiong Jiale¹²³⁴,An Junkai⁵⁶⁷⁸⁴,Yu Jicong⁹¹⁰⁴,Zhu Liping¹²³⁴,Feng Xing⁵⁶⁷⁸⁴,Jiang Xianxing¹²³⁴^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Sun Yat-Sen University

3. Guangzhou

4. China

5. Key Laboratory of Preclinical Study for New Drugs of Gansu Province

6. School of Basic Medical Sciences

7. Lanzhou University

8. Lanzhou

9. Testing and Inspection Center of Yangjiang City

10. Yangjiang

Abstract

The diastereodivergent asymmetric [3 + 2] cycloaddition ofN-2,2,2-trifluoroethylisatin ketimines with the identical catalysts was firstly performed, which leads to two diastereomeric bispiro[oxindole-bi-pyrrolidine]s.

Funder

National Natural Science Foundation of China

Guangdong Province Introduction of Innovative R&D Team

Recruitment Program of Global Experts

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C9QO00452A

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1. The relevance of chirality to the study of biological activity