Microfluidics for multiscale studies of biomolecular condensates-Reference-Cited by-同舟云学术

Microfluidics for multiscale studies of biomolecular condensates

Published:2023 Issue:1 Volume:23 Page:9-24
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Erkamp Nadia A.¹^ORCID,Qi Runzhang¹,Welsh Timothy J.¹,Knowles Tuomas P. J.¹²^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

2. Cavendish Laboratory, Department of Physics, University of Cambridge, J J Thomson Ave, Cambridge, CB3 0HE, UK

Abstract

Combining microfluidics with existing techniques allows for novel and more high-throughput measurements of the thermodynamics, kinetics and characteristics of biomolecular condensates.

Funder

Winston Churchill Foundation of the United States

FP7 Ideas: European Research Council

Frances and Augustus Newman Foundation

Cambridge Trust

Trinity College, University of Cambridge

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D2LC00622G

Reference124 articles.

1. RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

2. Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

3. Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

4. Phase separation of signaling molecules promotes T cell receptor signal transduction

5. The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

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