Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway-Reference-Cited by-同舟云学术

Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway

Published:2019 Issue:2 Volume:10 Page:1179-1190
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Wang Jia¹²³⁴⁵,Shen Wei¹²³⁴⁵,Zhang Jun-Yan¹²³⁴⁵,Jia Chang-Hao¹²³⁴⁵,Xie Mei-Lin¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmacology

2. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases

3. College of Pharmaceutical Sciences

4. Soochow University

5. Suzhou 215123

Abstract

Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis, and its mechanisms are associated with the increments of antioxidant ability, PPARγ activation, and Smad7 expression, which cause a synergistic inhibition of the NF-κB/TGF-β1/Smad signaling pathway.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/FO/C8FO01663A

Reference36 articles.

1. The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

2. Hypertensive myocardial fibrosis

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