Enhancement of ibuprofen solubility and skin permeation by conjugation with l-valine alkyl esters-Reference-Cited by-同舟云学术

Enhancement of ibuprofen solubility and skin permeation by conjugation with l-valine alkyl esters

Published:2020 Issue:13 Volume:10 Page:7570-7584
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Janus Ewa¹²³⁴⁵^ORCID,Ossowicz Paula¹²³⁴⁵^ORCID,Klebeko Joanna¹²³⁴⁵^ORCID,Nowak Anna⁶⁷⁸⁵^ORCID,Duchnik Wiktoria⁶⁷⁸⁵^ORCID,Kucharski Łukasz⁶⁷⁸⁵^ORCID,Klimowicz Adam⁶⁷⁸⁵^ORCID

Affiliation:

1. West Pomeranian University of Technology, Szczecin

2. Faculty of Chemical Technology and Engineering

3. Department of Chemical Organic Technology and Polymeric Materials

4. 71-065 Szczecin

5. Poland

6. Pomeranian Medical University in Szczecin

7. Department of Cosmetic and Pharmaceutical Chemistry

8. 70-111 Szczecin

Abstract

New ibuprofen derivatives made via conjugation with l-valine alkyl esters have better solubility in aqueous solutions and a lower log P value compared to the parent acid. They provide faster and more completely permeation of drug through the skin.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA00100G

Reference50 articles.

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4. The Effect of Selected Water-Soluble Excipients on the Dissolution of Paracetamol and Ibuprofen

5. Influence of Ethanol on the Solubility, Ionization and Permeation Characteristics of Ibuprofen in Silicone and Human Skin

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