Surface modification effect on contrast agent efficiency for X-ray based spectral photon-counting scanner/luminescence imaging: from fundamental study to in vivo proof of concept

Author:

Cuau Loic1,Akl Pia23,Gautheron A.24ORCID,Houmeau Angèle2,Chaput Frédéric1,Yaromina Ala5,Dubois Ludwig5,Lambin Philippe5ORCID,Karpati Szilvia1,Parola Stephane1ORCID,Rezaeifar B.56,Langlois Jean-Baptiste7,Si-Mohamed Salim A.23,Montcel Bruno2,Douek Philippe23,Lerouge Frederic1ORCID

Affiliation:

1. Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Laboratoire de Chimie, 46 allée d'Italie, F69364 Lyon, France

2. Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1294, F-69621, Lyon, France

3. Department of Radiology, Hospices Civils de Lyon, 69500 Bron, France

4. Université Jean Monnet Saint-Etienne, CNRS, Institut d'Optique Graduate School, Laboratoire Hubert Curien UMR 5516, F-42023, Saint-Etienne, France

5. Department of Precision Medicine, The M-Lab, GROW – School of Oncology, Maastricht University, Maastricht, 6200, MD, The Netherlands

6. Research group NuTeC, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium

7. CERMEP-imagerie du vivant, 59 boulevard Pinel, 69500 Bron, France

Abstract

X-Ray imaging techniques are among the most widely used modalities in medical imaging and their constant evolution has led to the emergence of new technologies.

Funder

HORIZON EUROPE European Innovation Council

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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