Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism-Reference-Cited by-同舟云学术

Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism

Published:2023 Issue:27 Volume:14 Page:7524-7536
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shaw Daniel J.¹^ORCID,Waters Lorna C.²,Strong Sarah L.²,Schulze Monika-Sarah E. D.³,Greetham Gregory M.⁴,Towrie Mike⁴,Parker Anthony W.⁴^ORCID,Prosser Christine E.³,Henry Alistair J.³,Lawson Alastair D. G.³,Carr Mark. D.²,Taylor Richard J.³,Hunt Neil T.¹^ORCID,Muskett Frederick W.²^ORCID

Affiliation:

1. Department of Chemistry and York Biomedical Research Institute, University of York, Heslington, York, YO19 5DD, UK

2. Department of Molecular and Cell Biology/Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK

3. UCB Pharma, UCB Biopharma UK, 216 Bath Road, Slough, SL1 3WE, UK

4. Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, Oxon, OX11 0QX, UK

Abstract

The varying dynamic nature of IL-17 dimers correlates to their affinity for IL-17 receptor A. An inhibitor of IL-17:receptor A binding was shown to rigidify IL-17A revealing an important new regulatory mechanism.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00728F

Reference56 articles.

1. IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis

2. Evidence that a neutrophil–keratinocyte crosstalk is an early target of IL ‐17A inhibition in psoriasis

3. IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis

4. Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A

5. Bimekizumab versus Secukinumab in Plaque Psoriasis

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Biomolecular infrared spectroscopy: making time for dynamics;Chemical Science;2024

2. Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507;Chinese Journal of Chemistry;2023-12-27