Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography-Reference-Cited by-同舟云学术

Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography

Published:2019 Issue:47 Volume:10 Page:10948-10957
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Conlon Patrick F.¹²³⁴^ORCID,Eguaogie Olga¹²³⁴^ORCID,Wilson Jordan J.¹²³⁴^ORCID,Sweet Jamie S. T.¹²³⁴^ORCID,Steinhoegl Julian⁵⁶⁷⁴^ORCID,Englert Klaudia⁸⁹¹⁰⁴,Hancox Oliver G. A.⁵⁶⁷⁴^ORCID,Law Christopher J.¹¹²¹²⁴,Allman Sarah A.⁵⁶⁷⁴^ORCID,Tucker James H. R.⁸⁹¹⁰⁴^ORCID,Hall James P.⁵⁶⁷⁴¹³^ORCID,Vyle Joseph S.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering

2. Queen's University Belfast

3. Belfast

4. UK

5. Reading School of Pharmacy

6. University of Reading

7. Reading RG6 6AP

8. School of Chemistry

9. University of Birmingham

10. Birmingham B15 2TT

11. School of Biological Sciences

12. Belfast BT9 5AH

13. Diamond Light Source

Abstract

Stable selenium-modified DNA which maintains the native tertiary structure has been prepared under automated conditions enabling SAD X-ray crystallography.

Funder

Engineering and Physical Sciences Research Council

Department for Employment and Learning, Northern Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC04098F

Reference88 articles.

1. Gene Synthesis Machines: DNA Chemistry and Its Uses

2. Large-scale de novo DNA synthesis: technologies and applications