Clonogenic assay and computational modeling using real cell images to study physical enhancement and cellular sensitization induced by metal nanoparticles under MV and kV X-ray irradiation

Author:

Hernández Millares Rodrigo1,Bae Chaewon2,Kim Seok-Jin3,Kim Taewan3,Park So-Yeon45,Lee Kangwon36ORCID,Ye Sung-Joon367ORCID

Affiliation:

1. Program in Biomedical Radiation Sciences, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea

2. Program in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea

3. Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea

4. Department of Radiation Oncology, Veterans Health Service Medical Center, Seoul, 05368, Republic of Korea

5. Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, 03080, Republic of Korea

6. Research Institute for Convergence Science, Seoul National University, Seoul, 08826, Republic of Korea

7. Advanced Institute of Convergence Technology, Seoul National University, Suwon 16229, Korea

Abstract

A study on the radiophysical dose enhancement and the intrinsic biological sensitization by gold and iron nanoparticles in A549 cancer cells.

Funder

Ministry of Trade, Industry and Energy

Ministry of Health and Welfare

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

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