Antimalarial activity of ruthenium(ii) and osmium(ii) arene complexes with mono- and bidentate chloroquine analogue ligands

Author:

Ekengard Erik12345,Glans Lotta12345,Cassells Irwin3678,Fogeron Thibault12345,Govender Preshendren3678,Stringer Tameryn3678,Chellan Prinessa3678,Lisensky George C.391011,Hersh William H.12131411,Doverbratt Isa15341617,Lidin Sven15341617,de Kock Carmen181920218,Smith Peter J.181920218,Smith Gregory S.3678,Nordlander Ebbe12345

Affiliation:

1. Inorganic Chemistry Research Group

2. Chemical Physics

3. Department of Chemistry

4. Lund University

5. SE-221 00 Lund

6. University of Cape Town

7. Rondebosch 7701

8. South Africa

9. Beloit College

10. Beloit

11. USA

12. Department of Chemistry and Biochemistry

13. Queens College and the Graduate Center of the City University of New York

14. Queens

15. Centre for Analysis and Synthesis

16. SE-22100 Lund

17. Sweden

18. Division of Pharmacology

19. Department of Medicine

20. University of Cape Town Medical School

21. Observatory 7925

Abstract

Thirteen new ruthenium and osmium half-sandwich complexes with chloroquine analogue ligands have been synthesized and evaluated for anti-malarial properties.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference51 articles.

1. Bioorganometallic chemistry—from teaching paradigms to medicinal applications

2. Bioorganometallics: Biomolecules, Labeling, Medicine, ed. G. Jaouen, Wiley-VCH, Weinheim, Germany, 2006

3. Bioorganometallic Chemistry and Malaria

4. C. Biot and D.Dive, in Medicinal Organometallic Chemistry, ed. G. Jaouen and N. Metzler-Nolte, Springer, 2010, pp. 155–194

5. Bioorganometallic Compounds with Antimalarial Targets: Inhibiting Hemozoin Formation

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