Real-time monitoring of the drying of extruded granules in a fluid-bed dryer using audible acoustic emission chemometrics

Author:

Aoki Hisayoshi1234,Hattori Yusuke1234,Otsuka Makoto1234

Affiliation:

1. Research Institute of Pharmaceutical Sciences

2. Faculty of Pharmacy

3. Musashino University

4. Tokyo 202-8585, Japan

Abstract

The purpose of this study was an attempt to adapt the audible acoustic emission (AAE) sound measurement method for the on-line monitoring of the fluid-bed drying process of pharmaceutical granules.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference35 articles.

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2. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, Pharmaceutical Development Q8 (R2), http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryinformation/Guidances/ucm073507.pdf, accessed August 2009

3. Towards Better Process Understanding: Chemometrics and Multivariate Measurements in Manufacturing of Solid Dosage Forms

4. Pharmaceutical Quality by Design: Product and Process Development, Understanding, and Control

5. Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes

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