Virtual screening, identification and <i>in vitro</i> validation of small molecule GDP-mannose dehydrogenase inhibitors-Reference-Cited by-同舟云学术

Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors

Published:2023 Issue:11 Volume:4 Page:865-870
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Dolan Jonathan P.¹²^ORCID,Ahmadipour Sanaz³,Wahart Alice J. C.¹²^ORCID,Cheallaigh Aisling Ní¹²,Sari Suat⁴,Eurtivong Chatchakorn⁵,Lima Marcelo A.²⁶^ORCID,Skidmore Mark A.²⁶^ORCID,Volcho Konstantin P.⁷,Reynisson Jóhannes²⁸^ORCID,Field Robert A.³^ORCID,Miller Gavin J.¹²^ORCID

Affiliation:

1. Lennard-Jones Laboratory, School of Chemical & Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK

2. Centre for Glycoscience, Keele University, Keele, Staffordshire, ST5 5BG, UK

3. Department of Chemistry & Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

4. Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Ankara, Turkey

5. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Si Ayutthaya Road, Ratchathewi, Bangkok 10400, Thailand

6. School of Life Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK

7. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia

8. Hornbeam Building, School of Pharmacy & Bioengineering, Keele University, Keele, Staffordshire, ST5 5BG, UK

Abstract

Identification of the first small molecule inhibitor for the guanosine diphosphate mannose dehydrogenase from Pseudomonas aeruginosa.

Funder

Engineering and Physical Sciences Research Council

Medical Research Council

Turkish Scientific and Technological Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00126A

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4. The Exopolysaccharide Alginate ProtectsPseudomonas aeruginosaBiofilm Bacteria from IFN-γ-Mediated Macrophage Killing

5. Role of alginate in infection with mucoid Pseudomonas aeruginosa in cystic fibrosis.