Synthesis and biological evaluation of 4β-benzoxazolepodophyllotoxin hybrids as DNA topoisomerase-II targeting anticancer agents-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of 4β-benzoxazolepodophyllotoxin hybrids as DNA topoisomerase-II targeting anticancer agents

Published:2015 Issue:118 Volume:5 Page:97314-97319
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Paidakula Suresh¹²³⁴,Kankala Shravankumar¹²³⁴⁵,Kankala Ranjith kumar⁶⁷⁸⁹,Juluru Bhasker¹²³⁴,Jonnalagadda Sreekantha B.⁵¹⁰¹¹¹²,Lee Chia-Hung⁶⁷⁸⁹,Vadde Ravinder¹²³⁴,Vasam Chandra Sekhar¹¹³⁴¹⁴¹⁵

Affiliation:

1. Department of Chemistry

2. Kakatiya University

3. Warangal

4. India

5. School of Physics and Chemistry

6. Department of Life Science and Institute of Biotechnology

7. National Dong Hwa University

8. Hualien

9. Taiwan

10. University of Kwazulu-Natal

11. Durban-4000

12. South Africa

13. Satavahana University

14. Department of Pharmaceutical Chemistry

15. Telangana University

Abstract

A series of new 4β-benzoxazolepodophyllotoxin compounds (9a–j) were prepared and screened for molecular modelling and cytotoxicity against various human tumour cell lines. Cell apoptosis evaluation was performed using Hoechst staining.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA15366B

Reference62 articles.

1. Podophyllotoxin and Deoxypodophyllotoxin in Juniperus bermudiana and 12 Other Juniperus Species: Optimization of Extraction, Method Validation, and Quantification

2. Endophyte Fungal Isolates from Podophyllum peltatum Produce Podophyllotoxin

3. Discovery of podophyllotoxins

4. Antineoplastic Agents. V. The Aromatic System of Podophyllotoxin (Part B)1-3

5. Antineoplastic and Antiviral Activities of Podophyllotoxin Related Lignans

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