Solvent-dependent regioselectivity of 2′-deoxyadenosine alkylation by 9-aminomethyl derivatives of SN38-Reference-Cited by-同舟云学术

Solvent-dependent regioselectivity of 2′-deoxyadenosine alkylation by 9-aminomethyl derivatives of SN38

Published:2019 Issue:48 Volume:43 Page:18975-18978
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Naumczuk B.¹²³⁴⁵^ORCID,Bocian W.¹²³^ORCID,Sitkowski J.¹²³⁴⁵^ORCID,Kawęcki R.⁶⁷⁸³^ORCID,Kozerski L.¹²³⁴⁵^ORCID

Affiliation:

1. National Medicines Institute

2. Chełmska 30/34

3. Poland

4. Institute of Organic Chemistry

5. Polish Academy of Sciences

6. University of Natural Sciences and Humanities

7. Faculty of Science

8. 3 Maja 54

Abstract

The investigated compounds in DMSO solution unexpectedly alkylate the N9 nitrogen of 2′-deoxyadenosine, whereas the N6 nitrogen atom is alkylated in water solution.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C9NJ04828F

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1. Recent Trends in Targeted Anticancer Prodrug and Conjugate Design

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