Alergia a Medicamentos Reportada em Crianças que Frequentam Infantários

Abstract

<strong>Introduction:</strong> Data about drug allergy prevalence in the general population, particularly in children, are lacking. This study aimed to estimate the prevalence of parent-reported drug allergy, in children attending day care centers in Lisbon and Oporto.<br /><strong>Material and Methods:</strong> In Phase II of the “ENVIRH study – Environment and Health in Children Day Care Centers”, a health questionnaire which included questions about drug allergies was administered to children by stratified, random sampling of day care centers.<br /><strong>Results:</strong> The final analysis included 1,169 questionnaires, 52.5% from boys. The mean age was 3.5 ± 1.5 years. The prevalence of reported drug allergy was 4.1% (95% CI: 3.0 - 5.2%). The most frequently reported drugs were antibiotics (27 cases) and NSAIDs (in 6 cases). In the multivariate analysis, reported drug allergy was directly associated with age (OR 1.19; 95% CI 1.01 - 1.41) and reported food allergy (OR 3.19; 95% CI 1.41 - 7.19). It was inversely associated with the level of parental education (OR 0.25; 95% CI 0.10 - 0.59).<br /><strong>Discussion:</strong> Even though the limitations of the study our results are in accordance with those reported by previous authors and suggest that there is a high prevalence of reported drug allergy in the considered age group.<br /><strong>Conclusion:</strong> A correct assessment of these situations is needed in order to avoid unnecessary drug evictions.<br /><strong>Keywords:</strong> Child Day Care Centers; Child; Drug Hypersensitivity; Prevalence; Portugal.