Author:
Pala Christine,Blake Stephanie M.
Abstract
Congenital diaphragmatic hernia (CDH) results from abnormal development of the diaphragm during fetal life, allowing abdominal organs to herniate through the defect into the thorax. Stunted lung growth is associated with pulmonary hypoplasia and pulmonary hypertension, which are the primary sources of morbidity and mortality for this population. Despite strides in neonatal and surgical care, the management of neonates with CDH remains challenging. Optimal treatment strategies are still largely unknown. Many centers utilize gentle ventilation, permissive hypercapnia, and pulmonary hypertension treatment inclusive of nitric oxide, sildenafil, or epoprostenol, delayed surgical repair, and extracorporeal membrane oxygenation (ECMO). Evidence-based guidelines are needed to enhance CDH care practices and better outcomes. The successful management of CDH is a collaborative team effort from the prenatal to the postnatal period and beyond.
Publisher
Springer Publishing Company
Subject
Critical Care and Intensive Care Medicine,Critical Care Nursing,General Medicine,Pediatrics, Perinatology and Child Health
Reference35 articles.
1. Addressing the hidden mortality in CDH: A population-based study
2. Crowley MA. Neonatal respiratory disorders. In: Martin RJ , Fanaroff AA , Walsh MC , eds. Fanaroff & Martin’s Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant . 11th ed. Elsevier; 2020:1203–1230.
3. The validity of the observed-to-expected lung-to-head ratio in congenital diaphragmatic hernia in an era of standardized neonatal treatment; a multicenter study
4. Sadler TW. The gut tube and the body cavities. In: Sadler TW , ed. Langman’s Medical Embryology . 14th ed. Wolters Kluwer; 2019:101–104.
5. Maternal risk factors and perinatal characteristics in congenital diaphragmatic hernia: A nationwide population-based study;Fetal Diagn Ther,2019