ABOUT INFORMATIONAL OPPORTUNITIES AND RESULTS OF EXPERIMENTAL STUDIES OF GDV VISUALIZATION PROTEIN-INDUCED MOLECULAR COMPLEXES IN AQUEOUS SOLUTIONS OF TABLETS, CONTAINING ANTIBODIES TO INTERFERON-γ
Author:
Maslennikova O.1, Sibirev A.2, Shipko M.2, Stepovich M.3
Affiliation:
1. Central State Medical Academy of Department of Presidential Affairs 2. Lenin Ivanovo State Power Engineering University 3. Tsiolkovsky Kaluga State University
Abstract
The character of changes in the positional order in the arrangement of protein-induced water associates in aqueous solutions of tableted drugs containing antibodies to interferon-γ was studied by the method of gas-discharge visualization. As objects of study, we used aqueous solutions of tablet forms, which were obtained by applying antibody solutions (with a concentration of 10–24 mg/ml) onto a carrier (89% raw lactose, 10% microcrystalline cellulose, 1% magnesium stearate). The informative possibilities of the gas-discharge visualization method in the analysis of data on the entropy, fractality, and length of emission isolines caused by kilovolt electrons released from aqueous solutions of tablet preparations containing antibodies to interferon-γ are considered. It has been shown that the activation of solutions by antibodies to interferon-γ is associated with the intensification of associative processes accompanied by the ordering of protein-induced molecular complexes. In general, the obtained results indicate the preservation of water associates formed in the process of ultrahigh dilution in solutions of tableted samples with antibodies to interferon.
Publisher
RIOR Publishing Center
Reference12 articles.
1. Epstein O. The Spatial Homeostasis Hypothesis. Symmetry, 2018, vol. 10, iss. 4, art. no. 103, doi: 10.3390/sym10040103., Epstein O. The Spatial Homeostasis Hypothesis. Symmetry, 2018, vol. 10, iss. 4, art. no. 103, doi: 10.3390/sym10040103. 2. Высоцкий В.И., Карлаш А.Ю. Особенности селективного транспорта и каналирования ионов в водной среде в каналах биологических мембран. Поверхность. Рентгеновские, синхротронные и нейронные исследования, 2010, № 12, с. 64-71., Vysotsky V.I., Karlash A.Yu. Features of selective transport and channeling of ions in the aquatic environment in the channels of biological membranes. Journal of Surface Investigation. X-ray, Synchrotron and Neutron Techniques, 2010, no. 12, pp. 64-71 (In Russ.). 3. Коротков К.Г., Орлов Д.В., Величко Е.Н. Применение метода газоразрядной визуализации для анализа различных жидкостей. Изв. вузoв, Приборостроение, 2011, т. 54, № 12, с. 40-46., Korotkov K.G., Orlov D.V., Velichko E.N. Application of the gas discharge imaging method for the analysis of various liquids. Izv. vuzov, Priborostroyeniye, 2011, vol. 54, no. 12, pp. 40-46 (In Russ.). 4. Шипко М.Н., Усольцева Н.В., Сибирев А.Л., Масленникова О.М., Смирнова А.И., Степович М.А., Габдулсадыкова Г.Ф. Влияние импульсных электромагнитных полей на позиционный и ориентационный порядок в водных растворах цетилтриметиламмония бромистого. Жидкие кристаллы и их практическое использование, 2018, т. 18, № 1, с. 47-54, doi: 10.18083/LCAppl.2018.1.47., Shipko M.N., Usol’tseva N.V., Sibirev A.L., Maslennikova O.M., Smirnova A.I., Stepovich M.A., Gabdulsadykova G.F. Influence of pulsed electromagnetic fields on positional and orientational ordering in aqueous solutions of cetyltrimethylammonium bromide (CTAB). Liquid Crystals and their Application. Russian Journal, 2018, no. 18, no. 1, pp. 47-54 (In Russ.). 5. Шипко М.Н., Степович М. А., Сибирев А.Л., Мельникова О.С., Смирнова А.И., Усольцева Н.В. Ориентационные эффекты при каналировании киловольтных электронов в жидких средах. Известия РАН. Серия физическая, 2020, т. 84, № 7, с. 994-997, doi: 10.31857/S0367676520070273., Shipko M.N., Stepovich M.A., Sibirev A.L., Melnikova O.S., Smirnova A.I., Usoltzeva N.B. Orientational Effects of Kilovolt Electron Channeling in Liquid Media. Bulletin of the Russian Academy of Sciences: Physics, 2020, vol. 84, no. 7, pp. 820-823 (In Russ.).
|
|