FEATURES OF PHOTOBIOMODULATION DURING ONCOGENESIS DEPENDING ON THE INTENSITY OF OXIDATIVE PROCESSES IN THE ORGANISM OF RATS

Abstract

In work tested the hypothesis that the antitumor efficacy of photobiomodulation (PBM) depends on the intensity of oxidative modification of macromolecules. The level of oxidative processes in the body was judged by the content of ROS-induced products of lipid, protein, and DNA modification, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase in biological tissues and fluids. It is proposed to use the behavioral activity of animals in the "open field" test as a non-invasive indicator for predicting the biological effects of photobiomodulation, indirectly reflecting the degree of oxidative stress in the body. It was shown that the level of behavioral activity correlates with SOD activity in the liver (ρ=0.8, p < 0.03, Spearman's test). Among laboratory rats, animals with passive, moderately active and highly active types of behavior can be distinguished. Each type is characterized by different severity of oxidative processes, growth dynamics of model solid tumors, and response to PBM in the violet-blue and red regions of the spectrum. Intraperitoneal exposure to ozonized saline with an ozone concentration of 0.16 μg/kg modulates the antitumor effect of PBM. It is concluded that the effectiveness of PMB during oncogenesis depends on the intensity of oxidative processes in the body and is interrelated with the behavioral characteristics of rats.