EFFECT OF OXIDATIVE STRESS ON THE FUNCTIONING OF GLUTAMATE RECEPTORS IN THE HIPPOCAMPUS
Author:
Aksenova S.1, Batova A.1, Bugay A.1, Dushanov E.1
Affiliation:
1. Joint Institute for Nuclear Research
Abstract
. In this work, we propose a model approach for analysis of the properties of hippocampal neural networks containing modified glutamate receptors. Molecular dynamics modeling of NMDA and AMPA receptors containing damage caused by the action of free radicals was carried out. The study of network activity of neurons with altered receptor structure was carried out in models of neural network CA3 of the hippocampus region. As a result of studying the properties of the neural network of the hippocampus with a modified structure of glutamate receptors, the electrophysiological characteristics of the known model of neural networks were obtained depending on the structure of the ion channel of the receptor. Based on the analysis of changes in the conductance of the ion channel, differences in the amplitude of the theta and gamma frequency ranges in neural networks with different model structures of AMPA and NMDA receptors were revealed. During the analysis of the network activity of neurons, changes in the conductance of the ion channel of glutamate receptors and local potential were revealed depending on the type of damage. With a significant decrease in the conductivity of the ion channel of the glutamate receptor in the neural network, a decrease in the amplitude of the theta-frequency and an increase in the gamma-frequency ranges is observed. In the case of damage to the TYR731 and CYS765 NMDA receptor in the neural network, an increase in the amplitude of the theta and gamma frequency ranges takes place.
Publisher
RIOR Publishing Center
Reference12 articles.
1. Sosa M., Gillespie A.K., Loren M., Frank L.M. Neural Activity Patterns Underlying Spatial Coding in the Hippocampus. Curr Top Behav Neurosci., 2018, vol. 37, pp. 43-100, doi: 10.1007/7854_2016_462., Sosa M., Gillespie A.K., Loren M., Frank L.M. Neural Activity Patterns Underlying Spatial Coding in the Hippocampus. Curr Top Behav Neurosci., 2018, vol. 37, pp. 43-100, doi: 10.1007/7854_2016_462. 2. Cravens C.J., Vargas-Pinto N., Christian K.M., Nakazawa K. CA3 NMDA receptors are crucial for rapid and automatic representation of context memory. EJN, 2006, vol. 24, pp. 1771-1780, doi: 10.1111/j.1460-9568.2006.05044.x., Cravens C.J., Vargas-Pinto N., Christian K.M., Nakazawa K. CA3 NMDA receptors are crucial for rapid and automatic representation of context memory. EJN, 2006, vol. 24, pp. 1771-1780, doi: 10.1111/j.1460-9568.2006.05044.x. 3. Huang S., Chen L., Bladen Chr., Stys P.K., Zamponi G.W. Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions. Molecular Brain, 2018, vol. 11, no. 62, doi: 10.1186/s13041-018-0406-3., Huang S., Chen L., Bladen Chr., Stys P.K., Zamponi G.W. Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions. Molecular Brain, 2018, vol. 11, no. 62, doi: 10.1186/s13041-018-0406-3. 4. Flores-Soto M.E., Chaparro-Huerta V., Escoto-Delgadillo M., Vazquez-Valls E., González-Castañeda R.E., Beas-Zarate C. Structure and function of NMDA-type glutamate receptor subunits. Neurología, 2012, vol. 27, no. 5, pp. 301-310, doi: 10.1016/j.nrleng.2011.10.003., Flores-Soto M.E., Chaparro-Huerta V., Escoto-Delgadillo M., Vazquez-Valls E., González-Castañeda R.E., Beas-Zarate C. Structure and function of NMDA-type glutamate receptor subunits. Neurología, 2012, vol. 27, no. 5, pp. 301-310, doi: 10.1016/j.nrleng.2011.10.003. 5. Wang C.C. et al. A critical role for GluN2B-containing NMDA receptors in cortical development and function. Neuron, 2011, vol. 72, pp. 789-805, doi: 10.1016/j.neuron.2011.09.023., Wang C.C. et al. A critical role for GluN2B-containing NMDA receptors in cortical development and function. Neuron, 2011, vol. 72, pp. 789-805, doi: 10.1016/j.neuron.2011.09.023.
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