THE ROLE OF THE IMMUNE MECHANISM IN THE DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION AND APOPTOSIS IN PREGNANT WOMEN WITH SEVERE COMPLICATIONS-Reference-Cited by-同舟云学术

THE ROLE OF THE IMMUNE MECHANISM IN THE DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION AND APOPTOSIS IN PREGNANT WOMEN WITH SEVERE COMPLICATIONS

Published:2023-05-24 Issue:1 Volume:4 Page:41-51
ISSN:2712-8164
Container-title:CASPIANJOURNALOF MEDICINE AND PHARMACY
language:en
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Author:

Kurlovich Ivan¹,Zubovskaya Elena¹,Buryak Dmitriy²,Peresada Olga³,Demidova Razaliya¹,Kapora Tamara¹,Beluga Maksim

Affiliation:

1. Republican Scientific and Practical Center «Mother and Child»

2. Republican Scientific and Practical Center «Mother and Child»,

3. Belarussian medical academy of postgraduate education

Abstract

In order to identify the role of cellular and humoral immunity, nonspecific resistance, cytokine spec-trum in the development of endothelial dysfunction and apoptosis in the pathogenesis of obstetric complications, 40 women with severe pregnancy complications and critical conditions associated with thrombotic micro angiopathy and 30 patients with physiologically occurring pregnancy were exam-ined. The assessment of cellular elements of peripheral blood, indicators of cellular and humoral im-munity, the level of cytokines, a disintegrin and metalloprotease with thrombospondin-1-like domains, member 13 (ADAMTS – 13), Willebrand factor, apoptosis-inducing factor, CD95, progesterone and the number of endotheliocytes is given. The conducted study indicates the failure of the functional state of both innate and acquired immunity in women with complicated pregnancy. The leading role in the development of endothelial dysfunction and the mechanism of apoptosis in pregnant women with severe complications and criti-cal cases associated with thrombotic microangiopathy belongs to an insufficient reserve of nonspecific resistance, impaired cellular and humoral immunity with low background progesterone level and high cytokine activity

Publisher

Astrakhan State Medical University

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