STUDY OF THE RELATIONSHIP BETWEEN THE ANTIMICROBIAL AND HYPOGLYCAEMIC ACTIVITIES OF NEW QUINAZOLINONES BY MATHEMATICAL MODELLING

Abstract

To date, quinazolinone derivatives, which have a unique chemical structure and exhibit a wide range of pharmacological activity, are used both as drugs and starting substances in the synthesis of deriva-tives with multitarget activity. Quinazolinones synthesized by the scientists of Volgograd Medical Uni-versity are characterized by the pronounced antimicrobial activity against Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Klebsiella. Computer-assisted prediction of the pharma-cological action spectrum by the PASS programme of the studied quinazolinone derivatives shows a high probability of their hypoglycaemic activity. The aim of the study was to establish the relationship between the mechanisms of antimicrobial and hypoglycemic activity and to substantiate the possibility of one type of pharmacological action as a consequence of the other. The application of mathematical modeling methods allowing to estimate the probability of formation of an intermediate complex com-pound between the drug substance and the intended target, as well as its strength, will allow to establish the "structure-activity" relationship and to characterize the possibility of unity of biochem-ical processes underlying the manifested pharmacological effects.