Author:
Sorzano C. O. S.,Jiménez A.,Mota J.,Vilas J. L.,Maluenda D.,Martínez M.,Ramírez-Aportela E.,Majtner T.,Segura J.,Sánchez-García R.,Rancel Y.,del Caño L.,Conesa P.,Melero R.,Jonic S.,Vargas J.,Cazals F.,Freyberg Z.,Krieger J.,Bahar I.,Marabini R.,Carazo J. M.
Abstract
Single-particle analysis by electron microscopy is a well established technique for analyzing the three-dimensional structures of biological macromolecules. Besides its ability to produce high-resolution structures, it also provides insights into the dynamic behavior of the structures by elucidating their conformational variability. Here, the different image-processing methods currently available to study continuous conformational changes are reviewed.
Funder
Ministerio de Economía, Industria y Competitividad, Gobierno de España
Comunidad de Madrid
Instituto de Salud Carlos III
Horizon 2020
National Institutes of Health
Publisher
International Union of Crystallography (IUCr)
Subject
Condensed Matter Physics,Genetics,Biochemistry,Structural Biology,Biophysics
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